In PTC Mathcad Prime 3.0 you have the ability to read and write HDF5 files using a custom function!
The HDF5 technology suite is designed to organize, store, discover, access, analyze, share, and preserve diverse, complex data in continuously evolving heterogeneous computing and storage environments. HDF5 supports all types of data stored digitally, regardless of origin or size. Petabytes of remote sensing data collected by satellites, terabytes of computational results from nuclear testing models, and megabytes of high-resolution MRI brain scans are stored in HDF5 files, together with metadata necessary for efficient data sharing, processing, visualization, and archiving.